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1/3

ABOUT

OF THE USA HAS HYPERTENSION

103

A TOTAL OF

POLYMORPHISMS IN THE BINDING POCKET OF THE AT1R WERE STUDIED

200

SOME ARBS ARE AMONG THE TOP

DRUGS ADMINISTERED IN THE USA

INTRODUCTION

     When patients are diagnosed with hypertension, they are often prescribed one of eight ARBs- Angiotensin Receptor Blockers.

     At the molecular level, cardiovascular diseases may be caused by a surplus of Angiotensin II binding to the Angiotensin Type 1 Recptor (AT1R), as Angiotensin II vasoconstricts blood vessels. ARBs are a popular and effective therapy because they block Angiotensin II from binding to the AT1R, and relieve the over-constriction of blood vessels. 

     But what happens when a patient has a polymorphism, a common mutation, which changes the structure of their AT1 Receptor?

     Will it render the drug ineffective?

     If so, is there a solution?

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ASNA TABASSUM

     As a junior at Ruben S. Ayala High School in Southern California, I have been incredibly enamored with the sciences- particularly biology and physics. In college, I hope to explore the intersection of science and policy. 

     Yet, when I'm not studying, I love public speaking, researching, and volunteering at my local hospital. My favorite novels include The Kite Runner and Wonder, but reading articles on Quora satiate my everyday curiosities.

     In the future, I plan to practice medicine abroad in underserved countries as well as conduct research. I am particularly interested in humantarian leadership as well as the cardiovascular field.

     Thank you for taking the time to read about my research efforts. I welcome any and all feedback- head to the Discussion page, and I will answer as soon as possible!

ACKNOWLEDGEMENTS

DR. BRADLEY ANDRESEN

For his generous and patient guidance, as well as relentless support. His readiness to advise the research was instrumental in completing the project at Western University of Health Sciences.

DR. YUN LUO

For her willingness to offer resources in her computational laboratory, as well as her generous guidance in difficult areas of the project.

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